||Union Carbide Corp., Danbury, CT.; Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
In both studies, beagle dogs were administered dietary concentrations of 2,000, 5,000 or 20,000 ppm. Those dogs administered the test material encapsulated in silica were found to exhibit reduced hemoglobin and hematocrit values, as well as abnormal erythroyote morphology. Histopathology revealed dose-related renal lesions. Chromium and lead levels were elevated in the liver, kidneys, bone and brain. In the other study, treatment-related effects also included a decrease in henoglobin and hematocrit values, as well as abnormal erythrocyte morphology. Histopathology revealed focal tubular nephrosis. Microscopic examination of brain and spinal cord revealed characteristic, lead-induced lesions in 4 of 8 dogs at the 20,000 ppm dose level. The content and chromium of the liver, kidney, and brain tissue were increased in all dogs.