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RECORD NUMBER: 40 OF 101

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Main Title

In Vivo Bone Marrow Chromosome Study in Rats with Acetone Cyanohydrin (Final Report) with Cover Letter dated 04/25/1986.

CORP Author

Center for Human Development, Jackson, MS.; Monsanto Chemical Co., Dayton, OH.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.

Year Published

1986

Report Number

878216400

Stock Number

OTS0510328

Additional Subjects

Toxicology ; Health effects ; Acetone Cyanohydrin (75-86-5) ; Genotoxicity ; Chromosomal Effects ; Mammals ; Rats ; Oral ; Gavage ; Toxic substances ; Laboratory animals ; CAS No 75-86-5

Holdings

Library	Call Number	Additional Info	Location	Last Modified	Checkout Status
NTIS	OTS0510328	Some EPA libraries have a fiche copy filed under the call number shown.		07/26/2022

Collation

79p

Abstract

The ability of acetone cyanohydrin to cause chromosome aberrations was evaluated in bone marrow cells of Sprague-Dawley CD rats (24/sex/group) receiving a single administration of test material at 0, 1.5, 5 or 15mg/kg by oral gavage. Sacrifice was at 6, 12, 24 and 48 hours after administration of test material. No statistically significant increases (KW-ANOVA) in the frequency of chromosome aberrations were observed at any dose level regardless of sacrifice time compared to the controls.

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