| Main Title |
Cho/hgprt Mammalian Cell Foward Gene Mutation Assay with Acetone Cyanohydrin with Cover Letter dated 04/25/1986. |
| CORP Author |
Pharmakon Research International, Inc., Waverly, PA.; Monsanto Chemical Co., Dayton, OH.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1986 |
| Report Number |
878216402 |
| Stock Number |
OTS0510330 |
| Additional Subjects |
Toxicology ;
Health effects ;
Acetone Cyanohydrin (75-86-5) ;
Genotoxicity ;
Gene Mutations ;
Mammals ;
Hamsters ;
In Vitro ;
Toxic substances ;
Laboratory animals ;
CAS No 75-86-5
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0510330 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
123p |
| Abstract |
The ability of acetone cyanohydrin to induce mutations at the HGPRT gene locus in Chinese Hamster Ovary (CHO) cells in vitro was evaluated in the presence and absence of Aroclor-induced rat liver S9 metabolic activation. Based on preliminary toxicity determinations, acetone cyanohydrin was tested for mutagenicity at 5 concentrations over the range of 100-950 ug/ml, with cell survival ranging from 101-37% without activation and 102-49% with activation. There were no significant differences between treated and control (untreated) cultures with respect to mutation frequencies at any of the concentrations tested, either with or withoutactivation. |
