Record Display for the EPA National Library Catalog

RECORD NUMBER: 7 OF 9

Main Title Salmonella Typhimurium/mammalian Microsome Plate Incorporation Assay with Acetone Cyanohydrin with Cover Letter dated 04/25/1986.
CORP Author Hazleton Labs. America, Inc., Madison, WI.; Monsanto Chemical Co., Dayton, OH.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1986
Report Number 878216403
Stock Number OTS0510331
Additional Subjects Toxicology ; Health effects ; Acetone Cyanohydrin (75-86-5) ; Genotoxicity ; Gene Mutations ; Bacteria ; In Vitro ; Toxic substances ; Laboratory animals ; CAS No 75-86-5
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
NTIS  OTS0510331 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 35p
Abstract
The mutagenicity of acetone cyanohydrin was evaluated in Salmonella tester strains TA98, TA100, TA1535, TA1537, and TA1538, both in the presence and absence of added metabolic activation by Aroclor-induced rat liver S9 fraction. Based on preliminary toxicity determinations, acetone cyanohydrin, diluted with DMSO, was tested for mutagenicity at concentrations of 0, 6.1, 18.3, 55.0, 165, and 495 ug/plate using the plate incorporation method. Acetone cyanohydrin was toxic to all the Salmonella strains at concentrations of 165 and 495 ug/ml without activation and at a concentration of 495 ug/ml with activation. Acetone cyanohydrin did not cause a reproducible positive response in any of the bacterial tester strains, either with or without metabolic activation.