Record Display for the EPA National Library CatalogRECORD NUMBER: 6 OF 15
|Main Title||Distribution of 2,4,5-Trichlorophenoxyacetic Acid in the Mouse Fetus.|
|Author||Courtney, K. D. ; Brown, M. T. ; Tucker., A. W. ;|
|CORP Author||Health Effects Research Lab., Research Triangle Park, N.C. Experimental Biology Div.|
|Stock Number||PB-284 757|
|Additional Subjects||Pesticides ; Herbicides ; Toxicology ; Pathology ; Tables(Data) ; Chlorine organic compounds ; Mice ; Laboratory animals ; Experimental data ; Excretion ; Urine ; Concentration(Composition) ; Tissues(Biology) ; Autoradiography ; Brain ; Liver ; Eye(Anatomy) ; Distribution ; Muscles ; Skin(Anatomy) ; Reprints ; Fetus ; T 2-4-5 herbicide ; Acetic acid/trichlorophenoxy ; Toxic substances ; Pesticide residues|
The herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) readily crosses the placenta in the mouse on gestational day 13. Concentrations of 2,4,5-T in maternal tissues and fetuses were obvious at 30 min., highest at 8 h, diminished by 24 h and almost entirely eliminated by 48 h. Autoradiographs of the whole fetus showed that initially 2,4,5-T was mainly in the highly vascularized tissues such as liver followed by the skin, eyes and ventricles of the brain. At 48 h, there was a general distribution of 2,4,5-T in the skeletal muscles. None was detected in the palate. The excretion rate in the mouse was approximately 60 micrograms/h; about 52% of the dose was recovered unchanged in the urine in 24 h.