The Health and Environmental Effects Profile for 2-methoxyethanol acetate was prepared to support listings of hazardous constituents of a wide range of waste streams under Section 3001 of the Resource Conservation and Recovery Act (RCRA) and to provide health-related limits for emergency actions under Section 101 of the Comprehensive Environmental Response, Compensation and Liability Act (CERCLA). Both published literature and information obtained from Agency program office files were evaluated as they pertained to potential human health, aquatic life and environmental effects of hazardous waste constituents. 2-methoxyethanol acetate has been determined to be a systemic toxicant. The daily exposure to the human population (including sensitive subgroups) that is likely to be without appreciable risk of deleterious effect during a lifetime, for 2-methoxyethanol acetate is 0.002 mg/kg/day for inhalation exposure. The Reportable Quantity (RQ) value for 2-methoxyethanol acetate is 100.