Record Display for the EPA National Library Catalog


Main Title Ultrastructure of the Paraquat Lung Lesion in the Rat.
Author Kimbrough, Renate D. ; Linder., Ralph E. ;
CORP Author Environmental Protection Agency, Chamblee, Ga. Office of Pesticides Programs.
Year Published 1972
Stock Number PB-279 722
Additional Subjects Herbicides ; Pesticides ; Toxicology ; Dosage ; Ingestion(Biology) ; Bioassay ; Rats ; Diet ; Laboratory animals ; Experimental data ; Lung ; Histology ; Pathology ; Reprints ; Paraquat ; Bipyridinium compounds ; Acetic acid/mercaptophenyl ; Toxic substances
Library Call Number Additional Info Location Last
NTIS  PB-279 722 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
Adult female Sherman strain rats were fed 500 ppm paraquat (1,1-dimethyl-4,4-bipyridylium dichloride) in their diet. Four poisoned as well as three control rats were sacrificed 1, 3, 5, 7 and 11 wk after onset of exposure. Two well-developed paraquat lung lesions were encountered. The alveoli of these lesions contained a very prominent amorphous material which was highly osmiophilic when examined with the electron microscope. It consisted of concentrically arranged whorls which were surrounded by or next to less electrondense lattice-like material. Additional ultrastructural findings in those and other lungs consisted of edematous and vacuolated membranous pneumocytes (type I) as well as endothelial cells. The granular pneumocytes were increased in 3 of 20 lungs of exposed animals.