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Main Title Teratology and Postnatal Studies in Rats of the Propylene Glycol Butyl Ether and Isooctyl Esters of 2,4-Dichlorophenoxyacetic Acid.
Author Unger, Timothy M. ; Kliethermes, Janet ; Van Goethem, Dan ; Short, Robert D. ;
CORP Author Midwest Research Inst., Kansas City, MO.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1981
Report Number 4604-B(3); EPA-68-02-2982; EPA-600/1-81-035;
Stock Number PB81-191140
Additional Subjects Pesticides ; Herbicides ; Toxicology ; Ingestion(Biology) ; Rats ; Pregnancy ; Chlorine organic compounds ; Esters ; Ethers ; Acetic acid/dichloro-(isooctyl-ester)-phenoxy ; Acetic acid/dichloro-(propylene-glycol-butyl-ether)-phenoxy ; D 2-4 herbicide ; Acetic acid/dichloro-phenoxy ; Teratogenesis ; Toxic substances
Library Call Number Additional Info Location Last
NTIS  PB81-191140 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 27p
The purpose of this study was to evaluate the teratogenic potential of the propylene glycol butyl ether (PGBE) and isooctyl (IO) esters of 2,4-dichlorophenoxyacetic acid (2,4-D). Accordingly, groups of pregnant CD rats received daily oral doses of PGBE or IO equivalent to 0, 6.25, 12.5, 25.0, or 87.5 mg/kg/day of 2,4-D from day 6 through day 15 of gestation, and fetuses were observed for gross, soft tissue, and skeletal defects. In addition, a postnatal study was performed on rats receiving 0, 12.5, or 87.5 ME/kg/day PGBE or IO to determine the effect of treatment on growth and survival of pups. No adverse effects were observed on maternal welfare, nor was there any evidence of embryo or fetal lethality in any of the treated groups. Of the anomalies observed, the incidence of lumbar (14th) rib buds was found to be statistically increased in the groups given the 87.5 mg/kg/day doses of both PGBE and IO. No other anomaly reached a level of statistical or toxicological significance. The number of pups per litter was significantly reduced on postpartum days 4 and 7 in dams receiving 87.5 ME/kg/day IO. However, mean pup body weight remained normal. Postnatal growth and survival of pups receiving PGBE were not adversely affected. It was concluded that PGBE and IO caused minor embryotoxicity which was not deleterious to growth and survival, and therefore was not teratogenic to offspring of treated rats.