Record Display for the EPA National Library Catalog


Main Title Inhibition of ATPase Activities of Brain and Liver Homogenates by Triethyltin (TET).
Author Jacobs, K. S. ; Lemasters, J. J. ; Reiter, L. W. ;
CORP Author North Carolina Univ. at Chapel Hill. School of Medicine.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA-R-809644; EPA/600/D-85/166;
Stock Number PB85-240646
Additional Subjects Adenosine phosphates ; Brain ; Liver ; Inhibitors ; In vitro analysis ; In vivo analysis ; Tin/triethyl ; ATP
Library Call Number Additional Info Location Last
NTIS  PB85-240646 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12p
In vitro, TET is an effective inhibitor of both mitochondrial and Na+/K+-ATPase activities in subcellular fractions from brain and liver. Although TET binds with high affinity to mitochondrial ATPase, it also binds to other cellular constituents including hemoglobin and myelin. Thus, whether or not ATPase inhibition is a factor in the in vivo toxicity of TET may depend on the ability of TET to bind to ATPases in the presence of other cellular constituents. The purpose of this study was to assess inhibition of ATPase activities in liver and brain homogenates in vivo or in vitro exposure to TET.