Record Display for the EPA National Library Catalog


Main Title Initial Submission: Letter from Du Pont Chemical to USEPA regarding Acute Inhalation Study in Rats with 1,5-Cyclooctadiene, dated 02/26/1996.
CORP Author Du Pont de Nemours (E.I.) and Co., Wilmington, DE.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1996
Report Number 8EHQ-0296-13593
Stock Number OTS0558467
Additional Subjects Toxicology ; Health effects ; Toxic substances ; 1 ; 5-cyclooctadiene ; Acute toxicity ; Mammals ; Rats ; Inhalation ; Neurotoxicity ; CAS No 111-78-4
Library Call Number Additional Info Location Last
NTIS  OTS0558467 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 3p
Groups of six rats were exposed nose only to atmospheres of the test material for four hours. The exposures were conducted at concentrations of 4300, 2700 or 1400 ppm. Mortalities of 4/6, 1/6, and 0/6 were observed at concentrations of 4300, 2700, and 1400 ppm, respectively. At 4300 ppm, the mortalities occurred during the exposure and the one death at 2700 ppm occurred overnight following the exposure. By three hours into the exposures, all rats failed to respond to external sound stimulus. Clinical signs noted in some rats immediately post-exposure included, immobility, lethargy, ataxia and/or abnormal gait. These clinical signs were not observed the day after exposure or during the remainder of the 14-day observation period. The Approximate Lethal Concentration (ALC) was 2700 ppm.