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Main Title Initial Submission: 3-Month Dietary Toxicity of Benzoic Acid, 2-Benzoyl-1-(1,1- Dimethylethyl)Hydrazide in Dogs with Cover Letter dated08/12/1992.
CORP Author Rohm and Haas Co., Spring House, PA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 8EHQ-0992-11019
Stock Number OTS0571056
Additional Subjects Toxicology ; Health effects ; Toxic substances ; Benzoic acid ; 2 ; benzoyl-1-(1 ; 1- dimethylethyl)hydrazide ; Chronic toxicity ; Mammals ; Dogs ; Oral ; Diet ; CAS No 112225-87-3
Library Call Number Additional Info Location Last
NTIS  OTS0571056 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 179p
RH-5849 (Toxicology Department Sample Number 87-172; lot no. WCT 2351, 99.6% active ingredient) was administered to 5 groups (4 dogs/sex/group) of Beagle dogs LRE Inc., Kalamazoo, MI, for 3 months at dietary concentrations of 0 (control), 10, 100, 400, and 1200 ppm of active ingredient (a.i.). All dogs were observed daily for signs of ill health or reaction to treatment and physical examinations were performed weekly. Feed consumption was monitored daily and body weights were monitored weekly beginning 2 weeks prior to treatment. Twice during the pre-test period and at 1 and 3 months after compound administra- tion, all dogs were bled for hematology and clinical chemistry analysis. Urinalysis, neurology, and ophthalmology examinations were performed on all dogs during the pre-test period and at week 13 of compound administration. At the end of 3 months of treatment, all dogs were killed, necropsied, selected organ weights recorded, and tissues collected for histological evaluation.