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RECORD NUMBER: 2 OF 4

OLS Field Name OLS Field Data
Main Title Initial Submission: Evaluation of the Teratogenicity of Inhaled 2,4-pentanedione in Fischer 344 Rats (Final Report) with Cover Letter Dated 10/31/1991.
CORP Author Mellon Inst.-Union Carbide Corp., Export, PA. Bushy Run Research Center.; Union Carbide Corp., Danbury, CT.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1991
Report Number 88-920000112
Stock Number OTS0534562
Additional Subjects Toxicology ; Health effects ; 2 ; 4-pentanedione ; Reproduction/fertility Effects ; Teratogenicity ; Mammals ; Rats ; Inhalation ; Toxic substances ; Laboratory animals ; CAS No 123-54-6
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NTIS  OTS0534562 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/10/2010
Collation 13p
Abstract
2,4-Pentadione (123-54-6) was evaluated for developmental effects in groups of 25 female Fischer rats administered the test substance by inhalation for 6 hours/day at concentrations of 0, 50, 200, or 400 ppm on days 6 through 15 of gestation. Animals were sacrificed on day 21 of gestation. Animals at 400 ppm showed signs of maternal toxicity (transient reduced body weight and reduced body weight gain during the exposure period). The 200 and 400 ppm groups showed reduced fetal body weights per litter. The incidences of external, visceral, skeletal and total malformations showed no differences from controls. The incidence of visceral variation and partial fetal atelectasis was increased at 400 ppm. Fetuses in this group also showed a consistent pattern of reduced skeletal ossification. The level of significance for all cases was p<0.05.