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RECORD NUMBER: 1 OF 4

OLS Field Name OLS Field Data
Main Title Copy of - 2,4-pentanedione, in Vivo Mouse Micronucleus Study with Cover Letter dated 12/05/1986.
CORP Author Mellon Inst.-Union Carbide Corp., Export, PA. Bushy Run Research Center.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1986
Report Number 89-870000070
Stock Number OTS0510542-1
Additional Subjects Toxicology ; Health effects ; 2 ; 4-pentanedione ; Genotoxicity ; Chromosomal Effects ; Mammals ; Mice ; Parenteral ; Intraperitoneal ; Toxic substances ; Laboratory animals ; CAS No 123-54-6
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NTIS  OTS0510542-1 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/10/2010
Collation 28p
Abstract
2,4-Pentanedione was evaluated for the ability to increase the incidence of micronucleated polychromatic erythrocytes in bone marrow of male and female Swiss-Webster mice treated by single i.p. injection (Micronucleus Test). Groups of at least 10 mice (at least 5 males and 5 females) were injected with 2,4-pentanedione in water vehicle at doses of 0, 200, 400 or 650 mg/kg (high-dose = approximately 89% of the LD50). The peripheral blood was sampled for micronucleus evaluation 30, 48, and 72 hrs after dosing. The ratio of normochromatic to polychromatic erythrocytes was not significantly different (p > 0.05, Fisher's Exact Test) inthe treated groups compared with the vehicle controls. Statistically significant increases in the numbers of micronuclei were observed at the 30-hr sampling time for male and female mice at the mid- and high-dose levels (p < or = 0.001) and at the 48-hr sampling for the combined sexes at all treatment levels (low-dose level, p < 0.05, and mid- and high-dose, p < or = 0.001).