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Main Title Acute Oral Toxicity (ld50) in Rats with Cover Letter Dated 06/25/1987.
CORP Author Springborn Inst. for Bioresearch, Inc., Spencerville, OH.; Occidental Chemical Corp., Grand Island, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1987
Report Number 86870000414
Stock Number OTS0513162
Additional Subjects Toxicology ; Health effects ; 1-chloro-4-methylbenzene (106-43-4) ; Acute Toxicity ; Mammals ; Rats ; Oral ; Gavage ; Toxic substances ; Laboratory animals ; CAS No 106-43-4
Library Call Number Additional Info Location Last
NTIS  OTS0513162 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 63p
Acute oral toxicity was evaluated in groups of 5 male and 5 female fasted Sprague-Dawley rats administered 4-chlorotoluene by gavage at a level of 1.7, 2.3, 3.3 or 4.6 g/kg. Mortality was observed in 2 males in the 1.7 g/kg group, 3 males and 4 females in the 2.3 g/kg group, and in all 5 males and females in the 3.3 and 4.6 g/kg groups. The LD50 was determined to be 2.1 g/kg (1.8 - 2.4 g/kg). Clinical observations included a decrease in motor activity, tremors, cyanosis, piloerection, excess salivation, chromodacryorrhea, increase in respiratory rate, decrease in respiratory rate and lacrimation. Gross necropsy revealed brightred or red and mottled lungs, stomach and intestinal irritation and cream colored, white or dark fluid in the stomach and intestine, red stained fur around the nose, 'blanched' stomachs and fluid filled stomachs.