Record Display for the EPA National Library Catalog


Main Title Acute Oral Dose Range-rats with Cover Letter Dated 06/25/1987.
CORP Author Hazleton Labs. America, Inc., Vienna, VA.; Occidental Chemical Corp., Grand Island, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1987
Report Number 86870000413
Stock Number OTS0513161
Additional Subjects Toxicology ; Health effects ; 1-chloro-4-methylbenzene (106-43-4) ; Acute Toxicity ; Mammals ; Rats ; Oral ; Gavage ; Toxic substances ; Laboratory animals ; CAS No 106-43-4
Library Call Number Additional Info Location Last
NTIS  OTS0513161 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
Acute oral toxicity was evaluated in groups of 2 adult male albino Sprague-Dawley rats administered para-chlorotoluene by gavage as either a 1.0 or 10% volume/volume solution in corn oil or in undiluted form at dosage levels of 10, 31.6, 100, 316, 1000 or 3160 ul/kg. Mortality was observed in both rats in the 3160 ul/kg dose group (100% solution) and the LD50 was estimated to be 1780 ul/kg. Clinical observations included depression, lacrimation, labored respiration, ataxia, tremors, depressed righting and placement reflexes and prostration. Gross necropsy revealed congestion of the lungs, kidneys and adrenals and inflammation of the gastrointestinal tract in the decedents. Sacrificed animals did not display this inflammation.