||Hazleton Labs. America, Inc., Vienna, VA.; Occidental Chemical Corp., Grand Island, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Acute oral toxicity was evaluated in groups of 2 adult male albino Sprague-Dawley rats administered para-chlorotoluene by gavage as either a 1.0 or 10% volume/volume solution in corn oil or in undiluted form at dosage levels of 10, 31.6, 100, 316, 1000 or 3160 ul/kg. Mortality was observed in both rats in the 3160 ul/kg dose group (100% solution) and the LD50 was estimated to be 1780 ul/kg. Clinical observations included depression, lacrimation, labored respiration, ataxia, tremors, depressed righting and placement reflexes and prostration. Gross necropsy revealed congestion of the lungs, kidneys and adrenals and inflammation of the gastrointestinal tract in the decedents. Sacrificed animals did not display this inflammation.