Record Display for the EPA National Library Catalog


Main Title Mutagenic and Carcinogenic Potency of Extracts of Diesel and Related Environmental Emissions: Study Design, Sample Generation, Collection, and Preparation (Journal Version).
Author Lewtas, J. ; Bradow, R. L. ; Jungers, R. H. ; Harris, B. D. ; Zweidinger, R. B. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1981
Report Number EPA-600/J-81-647;
Stock Number PB83-236885
Additional Subjects Exhaust emissions ; Toxicology ; Bioassay ; Exposure ; Epidemiology ; Reprints ; Mutagenesis ; Carcinogenesis ; Diesel engine exhaust ; Air pollution effects(Humans)
Library Call Number Additional Info Location Last
NTIS  PB83-236885 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
A major diesel emissions research program has been initiated by the US Environmental Protection Agency to assess the human health risk associated with increased use of diesel automobiles. This program is intended to establish the mutagenic and carcinogenic potency of complex organics associated with diesel particles as well as comparative particle-bound organics from other environmental emissions for which human epidemiological data are available. The mobile source samples selected for this study were collected from a heavy-duty diesel engine, a series of light-duty diesel passenger cars, and a gasoline catalyst automobile. The comparative source samples incorporated into the study were cigarette smoke condensate, coke oven emissions, roofing tar emissions, and benzo pyrene. The samples were tested using three mutagenic assays and four carcinogenic assays as prescribed by a test matrix. This report describes the study design, particle generation, and sample collection and preparation. A brief summary of the bioassays is also included.