| Main Title |
Effects of tributyltin on biomembranes : alteration of flow cytometric parameters and inhibition of Na(+)K(+)-ATPase two-dimensional crystallization / |
| Author |
Massaro, E. J. ;
Zucker, R. M. ;
Elstein, K. H. ;
Easterling, R. E. ;
Ting-Beall, H. P. ;
Allis, J. W.
|
| Other Authors |
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC. ;Duke Univ. Medical Center, Durham, NC. |
| Publisher |
U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory, |
| Year Published |
1988 |
| Report Number |
EPA/600/D-89/019 |
| Stock Number |
PB89-218192 |
| Subjects |
Risk assessment
|
| Additional Subjects |
Toxicity ;
Fluorescein ;
Crystallization ;
Fluorescence ;
Exposure ;
Cell nucleus ;
Hydrolysis ;
Membranes(Biology) ;
Tributyltin ;
Environmental pollution ;
Flow cytometry ;
Sodium potassium ATPASE ;
Enzyme inhibitors ;
Cultured tumor cells
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-218192 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
14 pages ; 28 cm |
| Abstract |
The cell interacts with its environment via the plasma membrane. Alteration of the composition/structure of this membrane can result in altered cell function. Therefore, the ability to detect subtle changes in the condition of the membrane may be of considerable value in predicting the response of cells to toxic insult. Tributyltin is a membrane-active toxicant of considerable environmental concern since it is extensively employed as a component of marine antifouling paints. Its effect on the murine erythroleukemic cell by flow cytometry has been investigated and has been observed to be toxic at extremely low levels (micromolar concentrations). These data have been utilized recently by the state of Virginia to lower their saltwater standard for this chemical. |
| Notes |
"Presented at the Proceedings of Hanford Life Sciences Symposium, Richland Washington (10/18-20/88) and submitted to Toxicology and Applied Pharmacology, vol. 96, pp. 393-403, 1988." EPA/600/D-89/019. PB89-218192. Includes bibliographical references. Microfiche. |
