Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Reproductive Toxicity Associated with Acrylamide Treatment in Male and Female Rats.
Author Zenick, H. ; Hope, E. ; Smith, M. K. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Cincinnati Univ., OH. Dept. of Environmental Health.
Year Published 1986
Report Number EPA/600/J-86/402;
Stock Number PB88-104120
Additional Subjects Reproduction(Biology) ; Toxicity ; Mutagens ; Sex behavior ; Breeding ; Fertility ; Rats ; Reprints ; Acrylamides ; Toxic substances ; Ataxia
Library Call Number Additional Info Location Last
NTIS  PB88-104120 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 18p
The present study was designed to evaluate the influence of acrylamide (ACR) on male and female reproductive function. Male rats received ACR in drinking water (50, 100, or 200 ppm) for up to 10 wk. Copulatory behavior, semen, and (for controls and 100 ppm only) fertility and fetal outcomes were evaluated. Females received ACR (25, 50, 100 ppm) for 2 wk prior to initiation of breeding and then throughout gestation and lactation. Hindlimb splaying was apparent in the 200-ppm males by wk 4; less severe splaying appeared in the 100-ppm group at wk 8. Disruptions in copulatory behavior preceded the appearance of this ataxia. These disruptions in mating performance interfered with ejaculatory processes and subsequent transport of sperm, since semen was found in the uterus of only 1 of the 15 females mated with the 10 -ppm males at wk 9. Moreover, only 33% of the females mated (wk 10) to the 100-ppm males were pregnant. Postimplantation loss was also significantly increased in the group. Hindlimb splaying appeared in the females receiving 100 ppm ACR during wk 1-2 of pregnancy. Body weight and fluid intake were also depressed. Dams in the 50-ppm group showed depression in these parameters during the last 2 wk of lactation. ACR did not significantly affect mating performance of the females, pregnancy rates, litter size, or survival. However, ACR did significantly depress pup body weight at birth (100-ppm group) and weight gain during lactation through postweaning, d 42 (50- and 100-ppm groups). Vaginal patency was delayed in the 100-ppm group only.