Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Factors Associated with Reduced Fertility and Implantation Rates in Females Mated to Acrylamide Treated Rats.
Author Sublet, V. H. ; Zenick, H. ; Smith, M. K. ;
CORP Author Health Effects Research Lab., Cincinnati, OH. ;Cincinnati Univ., OH. Dept. of Environmental Health.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/062;
Stock Number PB90-103680
Additional Subjects Fertility ; Toxicity ; Acrylamide ; Rats ; Male ; Female ; Reproduction(Biology) ; Germ cells ; Dose rate ; Reprints ; Animal sex behavior ; Fertilization ; Ovum implantation
Library Call Number Additional Info Location Last
NTIS  PB90-103680 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/10/1990
Collation 17p
A series of studies was conducted to examine the role of copulatory dysfunction, spermatotoxicity, and/or impaired fertilization in the reduced rates of fertility and implantation observed in females mated to acrylamide-treated male rats. In initial experiments, males were gavaged with 0, 5, 15, 30, 45, or 60 mg/kg acrylamide (ACR) for 5 days and then mated serially to naive females. ACR treatment reduced fertility and increased pre- and post-implantation loss, primarily over the first 3 weeks post-treatment. The data suggest that events critical to the fertilizing ability of the sperm appear to play a major role in the reduced reproductive competence associated with ACR treatment in male rats. (Copyright (c) 1989 Elsevier Scientific Publishers Ireland Ltd.)