Record Display for the EPA National Library Catalog


Main Title Studies of Echovirus-12 in Volunteers: Determination of Minimal Infectious Dose and the Effect of Previous Infection on Infectious Dose.
Author Schiff, G. M. ; Stefanovic, G. M. ; Young, E. C. ; Sander, D. S. ; Pennekamp, J. K. ;
CORP Author Christ Hospital, Cincinnati, OH. Inst. of Medical Research.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA-R-806173; EPA/600/J-84/298;
Stock Number PB85-203115
Additional Subjects Viruses ; Dosage ; Reprints ; Echoviruses
Library Call Number Additional Info Location Last
NTIS  PB85-203115 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
A two-part study of echovirus-12 was done in volunteers. In the first part the human infectious dose of the virus was determined in 149 healthy adults with undetectable serum antibody, each of whom drank 0-330,000 plaque-forming units (pfu) of virus in 100 ml of nonchlorinated water. Infection was defined as fecal shedding of virus or significant (fourfold or greater) increases in serum antibody titer. The HID(50) (i.e., the dose required for infection of 50% of the volunteers) was 919 pfu. Through statistical analysis of the data by probit transformation, a 1% human-infectious dose of 17 pfu was predicted.