Record Display for the EPA National Library CatalogRECORD NUMBER: 1 OF 7
|Main Title||Carcinogenicity and pesticides : principles, issues, and relationships. Biological issues in extrapolation. /|
|Author||Yang, Raymond S. H. ; Huff, J. ; Germolec, D. R. ; Luster, M. I. ; Simmons, J. E.|
|CORP Author||Health Effects Research Lab., Research Triangle Park, NC. ;PATHCO, Inc., Research Triangle Park, NC. ;Department of Agriculture, Washington, DC. ;Maryland Univ., College Park.;American Chemical Society, Washington, DC.|
|Publisher||U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,|
|Subjects||Pesticides--Carcinogenicity--Congresses ; Carcinogenesis--Congresses ; Carcinogens, Environmental--toxicity ; Neoplasms--chemically induced ; Pesticides--toxicity ; Carcinogens, Environmental--toxicity--congresses ; Neoplasms--chemically induced--congresses ; Pesticides--toxicity--congresses|
|Additional Subjects||Toxicology ; Pesticides ; Tables(Data) ; Extrapolation ; Reprints ; Carcinogenicity tests ; Risk assessment ; Species specificity ; Immune system|
|Collation||25 pages : illustrations ; 28 cm.|
To assess potential risks of chemicals to humans, extrapolation of the findings in laboratory animals to possible health effects in humans is inevitable. Several important biological issues must be considered in such a process; these include extrapolation between doses, species (including strain and sex), routes of administration and exposure regimens (e.g., intermittent vs constant rate). While there is no perfect surrogate for humans in the evaluation of carcinogenic potential and other toxicities of chemicals and other agents, rodents still represent the best models. Any imperfection in such a process (i.e., hazard identification and risk assessment of any given chemical or other agent) must be taken into consideration during extrapolation.
"Developed from a symposium sponsored by the Division of Agrochemicals at the 196th National Meeting of the American Chemical Society, Los Angeles, California, September 25-30, 1988." Includes bibliographical references. "Jane Ellen Simmons, project officer." Microfiche.