Record Display for the EPA National Library Catalog


Main Title Arterial Blood Gases, Pulmonary Function and Pathology in Rats Exposed to 0.75 or 1.0 ppm Ozone.
Author Pepelko, William E. ; Mattox, Joan K. ; Yang, You Yen ;
CORP Author Health Effects Research Lab., Cincinnati, OH.
Year Published 1980
Report Number EPA-600/J-80-179;
Stock Number PB81-148454
Additional Subjects Ozone ; Toxicology ; Rats ; Laboratory animals ; Pathology ; Exposure ; Body weight ; Blood gas analysis ; Respiratory system ; Reprints ; Toxic substances
Library Call Number Additional Info Location Last
NTIS  PB81-148454 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 14p
Arterial blood gases, residual lung volume (RV), deflation pressure volume (PV) curves, pulmonary pathology and body weight changes were studied in rats exposed up to 14 days to either 0.75 or 1.0 ppm ozone. Arterial PO2 and body weights decreased progressively with length of exposure while PaCO2 and RV increased. The slope of the PV curve decreased in all groups exposed to ozone. Pathological changes in the lung increased in severity with concentration and length of exposure. The present findings have shown that arterial blood gas measurements represent a sensitive index of altered lung function in rats, a species very sensitive to ozone exposure.