Record Display for the EPA National Library Catalog


Main Title Comparative Histopathological Effects of Chemically Contaminated Sediment on Marine Organisms.
Author Gardner, G. R. ; Yevich, P. P. ;
CORP Author Environmental Research Lab., Narragansett, RI.
Publisher c1988
Year Published 1988
Report Number ERNL-806 ;EPA/600/J-88/464;
Stock Number PB90-147828
Additional Subjects Malignant neoplasms ; Marine biology ; Black Rock Harbor ; Connecticut ; Exposure ; Reprints ; Carcinogenicity tests ; Mutagenicity tests ; Water pollution effects(Animals) ; Toxic substances ; Dose-response relationships
Library Call Number Additional Info Location Last
NTIS  PB90-147828 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
Comparative pathological effects in three species of fish and six species of invertebrates were investigated using a chemically contaminated sediment from Black Rock Harbor (BRH), Connecticut, USA. Substances contained in BRH sediment are known to be genotoxic, carcinogenic, co-carcinogenic and tumor-promoting. Proliferative lesions were observed in winter flounder (Pseudopleuronectes americanus) external, oral and esophageal epithelial surfaces, renal vascular and nephroblastic elements, and the pancreatic islets. Islet lesions included cystic adenomas and a diffuse islet proliferative condition, nesidioblastosis. In addition, pathology was enhanced when winter flounder were fed mussels (Mytilus edulis) previously exposed to BRH sediment. Neoplastic lesions developed in kidney tubule epithelia, gills, some regions of the gastrointestinal tract, neural elements and heart of oysters (Crassostrea virginica) exposed to BRH sediment for 30 days in the laboratory. In addition, renal carcinomas in three oysters had metastasized to the visceral ganglion. (Copyright (c) 1988 Elsevier Applied Science Publishers, Ltd.)