Record Display for the EPA National Library Catalog


Main Title Activity of Environmental Samples in a Cell Culture Test for Asbestos Toxicity.
Author Reiss, Betti ; Millette, James R. ; Williams, Gary M. ;
CORP Author American Health Foundation, Valhalla, NY. Naylor Dana Inst. for Disease Prevention.;Health Effects Research Lab., Cincinnati, OH.
Year Published 1980
Report Number EPA-R-803998; EPA-600/J-80-277;
Stock Number PB81-201139
Additional Subjects Toxicology ; Cultures(Biology) ; Asbestos ; Water pollution ; Cells(Biology) ; Bioassay ; Potable water ; Contaminants ; Reprints ; Particulates ; Drinking water ; Water pollution control ; NTISEPAORD
Library Call Number Additional Info Location Last
NTIS  PB81-201139 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
The inhibition of colony-forming efficiency of cultured human embryonic intestine-derived epithelial (I-407) cells was utilized in order to assay the toxic potential of six coded samples of particulate matter provided by the United States Environmental Protection Agency (EPA). The results of the assay indicated that the most toxic of the EPA samples tested 'blindly' was amosite which was equal in toxicity to the amosite used, by chance, as a positive control. The toxicities of the particulates from drinking water were approximately 100-fold less than the amosite; of these, the order of toxicity of the samples was San Francisco > Seattle > Duluth. The samples of attapulgite clay and taconite tailings displayed approximately half the toxicity of the drinking water particulates. These results indicate that this assay provides a sensitive and accurate method for screening asbestos and asbestiform contamination for potential toxicity.