| Main Title |
Enhancement of Benzo(a)Pyrene Mutagenicity by Chrysotile Asbestos in Rat Liver Epithelial Cells. |
| Author |
Reiss, B. ;
Tong, C. ;
Telang, S. ;
Williams, G. M. ;
|
| CORP Author |
American Health Foundation, Valhalla, NY. Naylor Dana Inst. for Disease Prevention.;Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1983 |
| Report Number |
EPA-R-803998.; EPA-600/J-83-163; |
| Stock Number |
PB84-170919 |
| Additional Subjects |
Toxicology ;
Asbestos ;
Rats ;
Liver ;
Epithelium ;
Cells(Biology) ;
Exposure ;
Reprints ;
Benzopyrene ;
Mutagenesis
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB84-170919 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
The co-mutagenicity of chrysotile asbestos and benzo(a)pyrene (B(a)P) was studied in adult rat liver (ARL-18) epithelial cells. Exposure to chrysotile alone did not increase the mutant incidence whereas B(a)P was mutagenic. Simultaneous exposure of the cells to chrysotile and B(a)P resulted in an enhanced mutant recovery compared to exposure to either of these substances alone. However, chrysotile did not enhance the mutagenicity of the carcinogen, N-methyl-N'-nitro-N-nitrosoguanidine. |
