||Effects of Subchronic Fourteen Day Exposure to Beneophyrene in B6C3F1 Female Mice on Host Resistance with Cover Letter 04/15/85.
Munson, A. E. ;
White, K. L. ;
Lysy, H. H. ;
||Medical Coll. of Virginia, Richmond. Dept. of Pharmacology and Toxicology.;American Petroleum Inst., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
B6C3F1 female mice ;
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A subcutaneous study was conducted with female B6C3F1 mice injected subcutaneously with 0, 5, 20 or 40 mg/kg benzo(a)pyrene (BaP) in corn oil vehicle daily for 14 days and then challenged with organisms or tumor cells at 4 challenge levels/BaP dose level. Subchronic exposure to BaP resulted in BaP dose-dependent increase in protection to Listeria monocytogenes infection. Exposure to BaP caused a dose-dependent increase in the pulmonary tumor burden of mice administered B16F10 melanoma cells intravenously 1 day after the last BaP exposure. Exposure to BaP caused a decrease in resistance to Herpes Simplex Type 2 virus (not dose-dependent) and Streptococcus pneumonia (dose-dependent). There was no effect observed due to exposure to BaP on the level of protection to Influenza A2.