Record Display for the EPA National Library Catalog


Main Title Humoral and Cell-Mediated Immune Status of Mice Exposed to TRANS-1,2-Dichloro ethylene.
Author Shopp, G. M. ; Sanders, V. M. ; White, K. L. ; Munson, A. E. ;
CORP Author Medical Coll. of Virginia, Richmond. Dept. of Pharmacology and Toxicology.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA-R-806481; EPA/600/J-85/418;
Stock Number PB86-213618
Additional Subjects Toxicology ; Immunology ; Bioassay ; Mice ; Exposure ; Dosage ; Reprints ; Ethylene/dichloro
Library Call Number Additional Info Location Last
NTIS  PB86-213618 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 17p
The study assessed possible adverse immunological effects of trans-1,2-dichloroethylene (DCE) on random-bred CD-1 mice following 14 and 90 days of exposure. A 14-day range-finding study was performed on male mice by gavage at doses 1/10 and 1/100 the LD50 (210 and 21 mg/kg). No alterations in either humoral or cell-mediated immunity were observed following the exposure. A 90-day study was conducted in which DCE was administered in the drinking water of male and female mice. The levels of DCE in the drinking water were calculated to deliver levels equivalent to, and higher than, those delivered for 14 days (17, 175, and 387 mg/kg for males and 23, 224, and 452 mg/kg for females). No changes were observed in the cellmediated immune status of either sex or in the humoral immune status of females.