Record Display for the EPA National Library Catalog


Main Title Study of the Relationship Between Carboxyhemoglobin on Admission to the Subsequent Hospital Course of Patients Admitted to the Myocardial Infarction Research Unit at the Johns Hopkins Hospital.
Author Radford, Edward P. ; Weisfeldt., Myron L. ;
CORP Author Coordinating Research Council, Inc., New York.;Johns Hopkins Univ., Baltimore, Md. School of Hygiene and Public Health.
Year Published 1975
Stock Number PB-248 224
Additional Subjects Myocardial infarction ; Cardiovascular diseases ; Carbon monoxide ; Humans ; Patients ; Angina pectoris ; Ischemia ; Coronary artery disease ; Exposure ; Smoking ; Pathology ; Blood circulation ; Blood chemical analysis ; Carbonylhemoglobin ; Air pollution effects(Humans) ; Cigarette smoking
Library Call Number Additional Info Location Last
NTIS  PB-248 224 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 25p
On the basis of current knowledge, chronic exposure to carbon monoxide could influence the onset or severity of a myocardial infarction by two main mechanisms. (1) Animal experiments have indicated that the atheromatous process can be accelerated by sustained high carboxyhemoglobin (COHb) levels. (2) Once a coronary occlusion occurs, the severity of ischemia could be increased by the presence of carbon monoxide even in relatively low concentrations. There is very little evidence in man supporting these hypotheses. This research was undertaken to investigate patients admitted to the Johns Hopkins Hospital Emergency Ward with symptoms of chest pain, to determine if carbon monoxide at admission might relate to the severity of the infarct. The possibility that chronic exposure might play a role in the severity was also evaluated. Previously Johns Hopkins issued a final report on the studies relating carboxyhemoglobin and sudden death in Baltimore, Maryland.