Record Display for the EPA National Library Catalog

RECORD NUMBER: 7 OF 12

Main Title Effects of Chlordimeform on Cardiovascular Functional Parameters. Part 3. Comparison of Different Routes of Administration in the Postweanling Rat.
Author Watkinson, W. P. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1986
Report Number EPA/600/J-86/324;
Stock Number PB87-179685
Additional Subjects Parenteral infusions ; Toxicity ; Blood pressure ; Heart rate ; Dosage ; Rats ; Laboratory animals ; Pesticides ; Reprints ; Chlordimeform
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
NTIS  PB87-179685 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 13p
Abstract
The effects of intraperitoneal (IP) administration of chlordimeform (CDM) were investigated in 22-24 day old pentobarbital-anesthetized Sprague-Dawley rats. Animals (N=32) received a single IP injection of either 10, 30, or 60 mg/kg CDM, or normal saline vehicle. Heart rate (HR) and electrocardiogram (ECG) were monitored for all animals, while body temperature was maintained at control levels (37 deg C). HR decreased 21-29% in the treated animals and there were no differences observed across dose groups or over time. ECG effects were confined to rate-related changes only. The decrease in HR produced by CDM in these animals was comparable to the delayed HR effect seen in previous studies from this laboratory (Watkinson, 1985; Watkinson, 1986) despite major differences in dosing regimens and routes of administration.