Revised edition of: Casarett & Doull's essentials of toxicology / editors, Curtis D. Klaassen, John B. Watkins III. 2nd ed. 2010. Includes bibliographical references and index.

Unit 1: General principles of toxicology. History and scope of toxicology -- Principles of toxicology -- Mechanisms of toxicity -- Risk assessment -- Unit 2: Disposition of toxicants. Absorption, distribution, and excretion of toxicants -- Biotransformation of xenobiotics -- Toxicokinetics -- Unit 3: Nonorgan-directed toxicity. Chemical carcinogenesis -- Genetic toxicology -- Developmental toxicology -- Unit 4: Target organ toxicity. Toxic responses of the blood -- Toxic responses of the immune system -- Toxic responses of the liver -- Toxic responses of the kidney -- Toxic responses of the respiratory system -- Toxic responses of the nervous system -- Toxic responses of the ocular and visual system -- Toxic responses of the heart and vascular system -- Toxic responses of the skin -- Toxic responses of the reproductive system -- Toxic responses of the endocrine system -- Unit 5: Toxic agents. Toxic effects of pesticides -- Toxic effects of metals -- Toxic effects of solvents and vapors -- Toxic effects of radiation -- Toxic effects of terrestrial animal -- Toxic effects of plants, fungi, and algae -- Unit 6: Environmental toxicology. Air pollution -- Ecotoxicology -- Unit 7: Applications of toxicology. Food toxicology -- Analytic/forensic toxicology -- Clinical toxicology -- Occupational toxicology. This book describes the science of toxicology, and includes important concepts from anatomy, physiology, and biochemistry to facilitate the understanding of the principles and mechanisms of toxicant action on specific organ systems. A summary of key points at the beginning and review questions at the end of each chapter help you study, understand, and memorize the material.