Record Display for the EPA National Library Catalog

RECORD NUMBER: 5 OF 27

OLS Field Name OLS Field Data
Main Title Development of a Toxicity Test System Using Primary Rat Liver Cells.
Author Inmon, Jeff ; Stead, Andy ; Waters, Michael D. ; Lewtas, Joellen ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1981
Report Number EPA-600/J-81-073;
Stock Number PB83-209841
Additional Subjects Toxicology ; Rats ; Liver ; Responses ; Dosage ; In vitro analysis ; Reprints ; Cytotoxicity
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB83-209841 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 9p
Abstract
A model in vitro rat liver parenchymal cellular toxicity system employing cells obtained by the in situ collagenase perfusion technique has been developed to detect potential liver toxicants. The initial evaluation of this test system was accomplished using cadmium chloride, chromium chloride, cobalt chloride, mercuric chloride, nickelous chloride, sodium arsenite, sodium selenite, and ammonium vanadate. Linear regression analysis of the dose response curves was used to determine the effective concentration at which the viability was reduced to 50%(EC50).