Record Display for the EPA National Library Catalog


Main Title Evaluation of Trace-Element Interactions Using Cultured Alveolar Macrophages.
Author Huisingh, Joellen L. ; Campbell, James A. ; Waters., Michael D. ;
CORP Author Health Effects Research Lab., Research Triangle Park, N.C. Environmental Toxicology Div. ;Northrop Services, Inc., Research Triangle Park, N.C.
Year Published 1977
Report Number EPA/600/J-77/097;
Stock Number PB-278 567
Additional Subjects Phagocytes ; Trace elements ; Mercury ; Cadmium ; Vanadium ; Toxicology ; Toxicity ; Metals ; In vitro analysis ; Cells(Biology) ; Alveoli pulmonis ; Rabbits ; Laboratory animals ; Lung ; Reprints ; Macrophages ; Cytotoxicity ; Air pollution effects(Humans)
Library Call Number Additional Info Location Last
NTIS  PB-278 567 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 14p
It is important to consider the interactions of toxic trace elements in an evaluation of the toxicity of environmental pollutants. The in vitro toxicity screening system, using the rabbit alveolar macrophage, provides a particularly useful system for evaluating trace-element interactions since crude particulates containing multiple trace elements can be introduced into the system. Mercury, cadmium, and vanadium are the three most toxic metals that have been tested in the macrophage system. When cells were exposed simultaneously to toxic concentrations of cadmium or mercury and nontoxic concentrations of sodium selenite, the macrophages had significantly higher viability, cell number, and adenosine triphosphate concentration than when they were exposed to the cadmium or mercury salts alone. In analogous experiments, zinc was found to protect against cadmium toxicity, and copper protected the macrophage against the lytic effects of vanadium.