Record Display for the EPA National Library CatalogRECORD NUMBER: 4 OF 9
|Main Title||Factors Determining the In vitro Response of Rodent Embryos to Teratogens.|
|Author||Sadler, T. W. ; Warner, C. W. ; Tulis, S. A. ; Smith, M. K. ;|
|CORP Author||North Carolina Univ. at Chapel Hill. School of Medicine.;Health Effects Research Lab., Research Triangle Park, NC.|
|Additional Subjects||Toxicology ; Bioassay ; In vitro analysis ; Mice ; Rats ; Embryos ; Laboratory animals ; Cadmium ; Teratogenesis ; Animal models ; Hydroxyurea ; Hydantoin/diphenyl ; Cyclophosphamide|
Four teratogens, with different modes of action and pharmacological properties, were selected and investigated in the embryo culture system. The compounds included hydroxyurea (HU), cadmium (Cd), diphenylhydantoin (DPH), and cyclophosphamide (CPP). The overall goal of the study was to characterize the response of early stage (2-6 somites) mouse and rat embryos to these agents in an effort to test the potential of utilizing the system of whole embryo culture for basic teratological and toxicological investigations and as a screening technique for teratogens. The paper summarizes the results of studies with these 4 compounds.