Record Display for the EPA National Library Catalog


Main Title Applied biopharmaceutics & pharmacokinetics /
Author Shargel, Leon,
Other Authors
Author Title of a Work
Yu, Andrew B. C.,
Wu-Pong, Susanna.
Publisher McGraw-Hill Medical,
Year Published 2012
OCLC Number 726074708
ISBN 9780071603935 (hardcover : alk. paper); 007160393X (hardcover : alk. paper); 9781259011115 (International ed.); 1259011119 (International ed.)
Subjects Biopharmaceutics ; Pharmacokinetics ; Models, Chemical
Library Call Number Additional Info Location Last
EKBM  RM301.4.S52 2012 Research Triangle Park Library/RTP, NC 09/15/2014
Edition 6th ed.
Collation xviii, 811 p. : ill. ; 25 cm.
Includes bibliographical references and index.
Contents Notes
Introduction to biopharmaceutics and pharmacokinetics -- Mathematic fundamentals in pharmacokinetics -- One-compartment open model: intravenous bolus administration -- Multicompartmental models : intravenous bolus administration -- Intravenous infusion -- Drug elimination and clearance -- Pharmacokinetics of oral absorption -- Multiple-dosage regimens -- Nonlinear pharmacokinetics -- Physiologic drug distribution and protein binding -- Drug elimination and hepatic clearance -- Pharmacogenetics -- Physiologic factors related to drug absorption -- Biopharmaceutic considerations in drug product design and in vitro drug product performance -- Drug product performance, in vivo : bioavailability and bioequivalence -- Impact of drug product quality and biopharmaceutics on clinical efficacy -- Modified-release drug products -- Targeted drug delivery systems and biotechnology products -- Relationship between pharmacokinetics and pharmacodynamics -- Application of pharmacokinetics to clinical situations -- Dosage adjustment in renal and hepatic disease -- Physiologic pharmacokinetic models, mean residence time, and statistical moment theory.