Record Display for the EPA National Library Catalog


Main Title Thermoregulation in Mice Following Acute Administration of Lead Acetate.
Author Gordon, C. J. ; Workman, R. A. ; Highfill, J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1987
Report Number EPA/600/J-87/223;
Stock Number PB88-171087
Additional Subjects Toxicology ; Thermoregulation ; Lead acetate ; Mice ; Laboratory animals ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB88-171087 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 6p
Several reports in the literature suggest a relationship between lead intoxication and thermoregulatory capacity. To investigate the effects of lead on the control of body temperature, mice of the BALB/c strain were injected intraperitoneally with lead acetate (0 to 100 mg/kg) while colonic temperature was measured 30, 60, and 90 min post-injection at ambient temperatures (Ta) of 20 and 30 C. Lead acetate caused a transient hypothermia, an effect which was augmented at cooler Ta's. In a second experiment, mice were injected with 100 mg/kg lead acetate and placed in a longitudinal temperature gradient to measure their preferred Ta. Lead acetate significantly reduced the preferred Ta during the first 30 min post-injection. Thus, lead acetate-treated mice selected a cooler Ta which augmented the lead-induced hypothermia. In a third experiment it was found that lead acetate-induced lethality was potentiated with increasing Ta. Hence, the hypothermic response to acute lead acetate treatment may be beneficial to survival.