Record Display for the EPA National Library Catalog


Main Title Behavioral Evaluation of the Irritating Properties of Ozone.
Author Tepper, J. S. ; Wood, R. W. ;
CORP Author Rochester Univ., NY. School of Medicine and Dentistry.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA-68-02-4032; EPA/600/J-85/110;
Stock Number PB85-244291
Additional Subjects Ozone ; Ammonia ; Air pollution ; Behavior disorders ; Exposure ; Concentration(Composition) ; Laboratory animals ; Mice ; Hazardous materials ; Reprints ; Air pollution effects(Human) ; Air pollution effects(Animals) ; Toxic substances
Library Call Number Additional Info Location Last
NTIS  PB85-244291 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
The sensory irritant properties of ozone have been considered to be responsible for symptoms that occur in humans after exposure. This assumption has not been studied explicitly. One way to assess the aversive properties of airborne irritants is to give the exposed individual an opportunity to control the duration of exposure, i.e., escape from the irritant. Mice were trained to turn off 100-ppm ammonia, a concentration that, in humans, is irritating to the upper airways. After the determination of ammonia concentration-effect curves, ozone was substituted for ammonia. Additional mice with no history of ammonia termination were trained to terminate ozone exposure, indicating that the aversive properties of ozone were not dependent on previous experience with other airborne irritants.