Record Display for the EPA National Library Catalog


Main Title New Metabolite of Chlorpyrifos: Isolation and Identification.
Author Lores, Emile M. ; Sovocool, G. Wayne ; Harless, Robert L. ; Wilson, Nancy K. ; Moseman., Robert F. ;
CORP Author Health Effects Research Lab., Research Triangle Park, N.C. Environmental Toxicology Div.
Year Published 1977
Report Number EPA/600/J-78/023;
Stock Number PB-283 568
Additional Subjects Pesticides ; Toxic diseases ; Metabolism ; Humans ; Poisons ; Ingestion(Biology) ; Liver ; Isolation ; Chemical analysis ; Gas chromatography ; Mass spectroscopy ; Nuclear magnetic resonance ; Phosphorus organic compounds ; Toxicology ; Reprints ; Metabolites ; Pesticide residues ; Dursban ; Phosphorothioates ; Methane thiols ; Toxic substances
Library Call Number Additional Info Location Last
NTIS  PB-283 568 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 7p
A new metabolite of chlorpyrifos was discovered in a human poisoning case in which a lethal quanitity of the pesticide was ingested. The metabolite was isolated from a human liver extract. After extensive cleanup, the metabolite was subjected to various instrumental analyses such as gas chromatography, mass spectrometry, and nuclear magnetic resonance. The metabolite was identified as a compound similar to chlorpyrifos with a methylthio (-SCH3) group substituted for a chlorine on the pyridinol ring. The method of isolation and the data obtained from the instrumental analyses are presented.