Record Display for the EPA National Library Catalog
RECORD NUMBER: 5 OF 27
|OLS Field Name||OLS Field Data|
|Main Title||Development of a Toxicity Test System Using Primary Rat Liver Cells.|
|Author||Inmon, Jeff ; Stead, Andy ; Waters, Michael D. ; Lewtas, Joellen ;|
|CORP Author||Health Effects Research Lab., Research Triangle Park, NC.|
|Additional Subjects||Toxicology ; Rats ; Liver ; Responses ; Dosage ; In vitro analysis ; Reprints ; Cytotoxicity|
A model in vitro rat liver parenchymal cellular toxicity system employing cells obtained by the in situ collagenase perfusion technique has been developed to detect potential liver toxicants. The initial evaluation of this test system was accomplished using cadmium chloride, chromium chloride, cobalt chloride, mercuric chloride, nickelous chloride, sodium arsenite, sodium selenite, and ammonium vanadate. Linear regression analysis of the dose response curves was used to determine the effective concentration at which the viability was reduced to 50%(EC50).