||Use of Genetic Activity Profiles in Hazard Evaluation.
Waters, M. D. ;
Stack, H. F. ;
Brady, A. L. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC.
Hazardous materials ;
Mutagenicity tests ;
Laboratory animals ;
Health effects ;
Risk assessment ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
A methodology has been developed to display and evaluate multiple test quantitative information on genetic toxicants for purposes of hazard/risk assessment. Dose information is collected from the open literature: either the lowest effective dose or the highest ineffective dose tested is recorded for each agent and bioassay system. For each agent in the data base, the quantitative results from genetic and related test systems are represented by computer-generated bar graphs 'genetic activity profiles.' Bioassay systems are organized according to classes of genetic activity and subdivided by the phylogenetic level of the test organism. Genetic activity profiles were prepared 187 chemicals, e.g., dibromochloropropane, for the use of the International Agency for Research on Cancer (IARC) Working Group.