|Health risk assessment : dermal and inhalation exposure and absorption of toxicants /
|0849373573 (acid-free paper) 9780849373572 (acid-free paper)
Gases, Asphyxiating and poisonous--Toxicology ;
Air Pollutants, Environmental--toxicity ;
Dose-Response Relationship, Drug ;
Environmental Pollutants--toxicity ;
Risk Factors ;
Skin Absorption ;
|Research Triangle Park Library/RTP, NC
|527 p. : ill., map ; 27 cm.
Includes bibliographical references and index.
Physiologically based pharmacokinetic modeling to predict tissue dose and cholinesterase inhibition in workers exposed to organophosphorus and carbamate pesticides -- Application of pharmacokinetic mosels to predict target dose -- Cytochrome P450-dependent metabolism of drugs and carcinogens in skin -- Percutaneous absorption -- In vitro skin metabolism -- Animal models for percutaneous absorption -- Comparative study of the kinetics and bioavailability of pure and soil-absorbed benzene, toluene, and m-xylene after dermal exposure -- Prediction of human percutaneous absorption with physicochemical data -- Dermal absorption of TCDD: effect of age. (cont) Percutaneous absorption of chemicals from water during swimming and bathing -- Percutaneous absorption of contaminants from soil -- General overview on toxicological responses and routes of chemical exposure -- Acute toxicity testing by the dermal route -- Subchronic dermal exposure studies with industrial chemicals -- Dose response of percutaneous absorption -- Reproductive and developmental toxicity studies by cutaneous administration -- Dermal carcinogenicity studies of petroleum-derived materials -- Comparison of results from carcinogenicity tests of two halogenated compounds by oral, dermal, and inhalation routes -- Objectives and goals of dermal carcinogenicity testing of petroleum liquids. (cont) Chemical carcinogenesis in skin: causation, mechanism, and role of oncogenes -- Incorporating biological information into the assessment of cancer risk to humans under various exposure conditions and issues related to high background tumor incidence rates -- Phototoxicity of topical and systemic agents -- Techniques for assessing the health risks of dermal contact with chemicals in the environment -- Interspecies extrapolation of toxicological data -- Human skin xenografts to athymic rodents as a system to study toxins delivered to or through the skin -- Isolated perfused porcine skin flap -- Perspectives on
assessment of risk from dermal exposure to polycyclic aromatic hydrocarbons -- Paradox of herbicide 2,4-D epidemiology -- Review of epidemiologic studies with regard to routes of exposure to toxicants.