Record Display for the EPA National Library Catalog


Main Title 2-Methoxyethanol, 2-(2-Methoxyethoxy) Ethanol, 2-(2-Ethoxyethoxy)Ethanol, 2-(2-Butoxyethoxy)Ethanol: Absorption through Human Skin in Vitro with Cover Letter dated 10/03/84.
Author Walker, M. ; Scott, R. C. ;
CORP Author Imperial Chemical Industries Ltd., Alderley Park (England). Central Toxicology Lab.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher Oct 1984
Year Published 1984
Report Number FYI-AX-1084-0178-SU ;CTL/T/752;
Stock Number OTS-0000178-2
Additional Subjects Human skin ; Absorption ; Glycol ethers ; Diffusion barriers ; Epidermis ; Hazards ; 2-(2-methoxyethoxy)ethanol ; 2-(2-ethoxyethoxy)ethanol ; 2-(2-butoxyethoxy)ethanol
Library Call Number Additional Info Location Last
NTIS  OTS-0000178-2 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 125p
The in vitro absorption of four glycol ethers (2-methoxyethanol, 2-(2-methoxyethoxy)ethanol) through human skin has been measured from the neat liquid. The mean study rates of absorption were: 2-methoxyethanol 1.66mg/cm(sup 2)/4 (SD + or - 0.79; n = 10); 2-(2-methoxyethoxy)ethanol 0.21mg/cm(sup 2)/hr (SD + or - 0.16; n = 11); 2-(2-ethoxyethoxy)ethanol 0.13mg/cm(sup 2)/hr (SD + or - 0.11; n = 10); and 2-(2-butoxyethoxy)ethanol 0.033mg/cm(sup 2)/hr (SD + or - 0.02; n = 9). The results indicate that apart from the 2-methoxyethanol, the other glycol ethers penetrated the epidermis slowly, when applied as a neat liquid. None of the glycol ethers studied as judged by tritiated water permeability determinations, were shown to alter significantly the 'diffusion barrier' properties of the epidermal membranes following eight hours continual contact.