Record Display for the EPA National Library Catalog

RECORD NUMBER: 11 OF 27

Main Title In vitro Modeling in Neurotoxicology.
Author Veronesi, B. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1986
Report Number EPA/600/D-86/004;
Stock Number PB86-145430
Additional Subjects Toxicology ; In vitro analysis ; Models ; Neoplasms ; Bioassay ; Neurotoxicology ; Cell lines
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB86-145430 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 39p
Abstract
Many toxicologists in academic, industrial and governmental sectors consider in vitro (i.e. cell and tissue culture) alternatives to animal toxicity testing as inevitable given the sheer volume of new chemicals and the time and cost confines of conventional methodologies. For Neurotoxicologists, in vitro systems ranging from tumor cell lines (i.e., neuroblastomas, gliomas, and pheochromocytomas) to organotypic explants provide rapid, inexpensive models for either screening putative neurotoxicants or addressing their mechanisms(s) of action. Ideally, a variety of methodologies are available to the investigator, since no single technique will be able to detect all possible neurotoxic and-points. Assuming the accessibility, a chemical's toxic potential can best be addressed using a tier approach in which neurotoxic assessment progresses from the simple, inexpensive and less specific assay (e.g., cell lines) to the more complex, technically demanding and definitive assay (e.g., tissue explant).