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Main Title Preliminary report on the mutagenicity of carbaryl
Author Vaughan-Dellarco, V.
CORP Author United States. Environmental Protection Agency.
Publisher Reproductive Effects Assessment Group, Office of Health and Environmental Assessment, U.S. Environmental Protection Agency ;
Year Published 1981
Report Number EPA/600/6-81/001
Stock Number PB81-200768
OCLC Number 08266821
Additional Subjects Chemical mutagenesis ; Insecticides ; Pesticides ; Carbamates ; Mutations ; In vitro analysis ; Bacteria ; Drosophila ; Cells(Biology) ; Chromosomes ; Bioassay ; Carbaryl ; Mutagenesis ; Metabolites
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJED  EPA 600/6-81-001 OCSPP Chemical Library/Washington,DC 01/01/1988
ESAD  EPA 600-6-81-001 Region 10 Library/Seattle,WA 01/29/1999
NTIS  PB81-200768 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation iii, 43 p. ; 28 cm.
Carbaryl has been reported to cause point mutations in bacteria, Drosophila, and mammalian cells in vitro; unscheduled DNA synthesis in human cells in culture; and chromosome effects (including spindle effects) in plants, mammalian cells in vitro, and animals. Although there are inadequacies in these studies, the results when considered together are strongly suggestive that carbaryl may have the intrinsic ability to act as a mutagen. It should be noted that because carbaryl appears to act as a weak mutagen in the experimental test systems, it is likely to act as a weak mutagen in humans as well. To cause heritable effects in humans, however, carbaryl and/or an active metabolite(s) must reach the germinal tissue. Evidence that carbaryl reaches the mammalian gonad is considered suggestive. Adverse gonadal effects, e.g., abnormal sperm morphology (Degraeve et al. 1976), reduction in the number of spermatogonia and spermatozoa in the seminiferous tubules, (Kitagawa et al. 1977) reduced sperm motility (Shtenberg and Rybakova 1968), and decreased fertilization index (Collins et al. 1971) have been reported in rodents exposed to carbaryl. In addition, abnormal sperm head morphology has been reported in workers with known exposure to carbaryl (Wyrobek et al. 1980). Therefore, carbaryl may have the potential to act as a germ-cell mutagen.
Cover title. January 1981. EPA 600-6-81-001. PB81-200 768. Prepared for Special Pesticide Review Division, Office of Pesticide Programs.