Record Display for the EPA National Library Catalog


Main Title Carcinogenic effects of Benzene : an update.
Author Bayliss, D. L. ; Chen, C. ; Sonawane, B. ; Valcovic, L.
CORP Author Environmental Protection Agency, Washington, DC. National Center for Environmental Assessment.
Publisher U.S. Environmental Protection Agency, Office of Research and Development,
Year Published 1997
Report Number EPA/600/P-97/001A; NCEA-W-0268
Stock Number PB97-188379
OCLC Number 37273183
Subjects Benzene--Toxicology ; Carcinogenesis ; Benzene--toxicity ; Carcinogens, Environmental
Additional Subjects Benzene ; Health effects ; Risk assessment ; Toxicity ; Health hazards ; Dose-response relationships ; Environmental exposure pathway ; Occupational exposure ; Children ; Pathogenesis ; Metabolism ; Malignant neoplasms ; Mortality ; Leukemia ; Carcinogenicity
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EHAD  EPA/600-P-97-001A Region 1 Library/Boston,MA 08/15/1997
EHBD  EPA/600/P-97/001A CEMM/ACESD Library/Narragansett,RI 02/23/2007
EJED  EPA 600/P-97-001A OCSPP Chemical Library/Washington,DC 07/18/1997
EKBD  EPA-600/P-97-001A Research Triangle Park Library/RTP, NC 12/19/1997
EKCD  EPA/600/P-97/001 CEMM/GEMMD Library/Gulf Breeze,FL 10/02/2018
ELBD ARCHIVE EPA 600/P-97/001A Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
ELBD  EPA 600-P-97-001A AWBERC Library/Cincinnati,OH 07/18/1997
EMBD  EPA/600/P-97/001A NRMRL/GWERD Library/Ada,OK 09/27/1997
ERAD  EPA 600/P-97-001A Region 9 Library/San Francisco,CA 11/20/1998
ESAD  EPA 600-P-97-001A Region 10 Library/Seattle,WA 07/31/1998
NTIS  PB97-188379 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation v, 43 pages : illustrations ; 28 cm
The major issue addressed in this document involves the nature and magnitude of the risk of cancer to humans exposed to low levels of benzene. Occupational studies continue to provide the bulk of evidence of benzene's carcinogenicity. This document reconfirms that benzene is a known human carcinogen by all routes of exposure. This finding is supported by evidence from human epidemiologic studies, animal data, and an improvement in understanding of mechanisms of action. Human epidemiologic studies of highly exposed occupational cohorts have demonstrated that exposure to benzene can cause acute nonlymphocytic leukemia and other blood disorders, that is, preleukemia and aplastic anemia. Additionally, changes in blood and bone marrow consistent with hematoxicity are recognized in humans and experimental animals. Currently, there is insufficient evidence to reject a linear dose-response curve for benzene in the low dose region, i.e., that benzene is, in fact, nonlinear in its effects. Because this knowledge is not available at the present time, the Agency's approach of using a model with low dose linearity is still recommended.
"EPA/600/P-97/001A."--Cover. "June 1997"--Cover. "Review Draft (Do Not Cite or Quote)"--Cover. "External Review Draft." "U.S. Environmental Protection Agency." Includes bibliographical references (pages 34-43).