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Main Title Interspecies Comparisons of A/D Ratios: A/D Ratios Are Not Constant Across Species.
Author Daston, G. P. ; Rogers, J. M. ; Versteeg, D. J. ; Sabourin, T. D. ; Baines, D. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Developmental Toxicology Div. ;Procter and Gamble Co., Cincinnati, OH. Human and Environmental Safety Div. ;Battelle, Columbus, OH.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-92/024;
Stock Number PB92-143965
Additional Subjects Toxicity ; Teratogens ; Species specificity ; Invertebrates ; Laboratory animals ; Lethal dosage ; Toxic substances ; Tables(Data) ; Amphibia ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB92-143965 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 29p
The hypothesis that the ratio of the adult (A) and developmental (D) toxicity of a chemical is constant across animal species has been proposed as the basis for identifying developmental hazards, both from traditional developmental toxicity screens using laboratory mammals and from alternative systems such as the coelenterate Hydra attenuata. The purpose of the study was to determine whether A/D ratios are constant across species. The developmental and adult toxicity of 14 chemicals was assessed in four phylogenetically different species. The chemicals tested were aminopterin, bromodeoxyuridine, cadmium chloride, caffeine, congo red, dinocap, dinoseb, diphenylhydantoin, epinephrine, ethylenethiourea, 2-methoxyethanol, mirex, all-trans-retinoic acid, and trypan blue. Data indicate that A/D ratios are not constant across these representative species, and there is no basis for using A/D for hazard assessment.