Record Display for the EPA National Library Catalog


Main Title Structure-Toxicity Relationships for alpha, beta-Unsaturated Alcohols in Fish.
Author Mckenyan, O. M. ; Veith, G. D. ; Bradbury, S. P. ; Russom., C. L. ;
CORP Author Environmental Research Lab.-Duluth, MN. ;Wisconsin Univ.-Superior. Lake Superior Research Inst.
Publisher c1993
Year Published 1993
Report Number EPA/600/J-94/187;
Stock Number PB94-163664
Additional Subjects Fishes ; Toxicity tests ; Chemical reactions ; Biochemistry ; Alcohols ; Unsaturated hydrocarbons ; Metabolism ; Molecular structure ; In vivo analysis ; In vitro analysis ; Carbonyl ; Acetylene ; Response ; Animal behavior ; Toxic tolerances ; Reprint ; Pimephales promelas ; Proparglic alcohols ; Fathead minnows ; Electrophiles
Library Call Number Additional Info Location Last
NTIS  PB94-163664 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 6p
Previous toxicity testing with fathead minnows (Pimephales promelas) indicated that some unsaturated acetylenic and allylic alcohols can be metabolically activated, via alcohol dehydrogenase, to highly toxic alpha, Beta-unsaturated aldehydes and ketones or allene derivatives. Although several in vivo and in vitro toxicological and biochemical endpoints can differentiate these alcohols by toxic mechanism, the use of stereoelectronic molecular descriptors to discriminate these toxicants, and subsequently to predict potency, has not been previously attempted. Exploration of several descriptors indicated that soft electrophilic characteristics of acetylenic or allylic moieties in the suspected metabolites unambiguously discriminated reactive and narcotic toxicants. (Copyright (c) 1993 VCH Verlagsgesellschaft.)