| Main Title |
Structure-Toxicity Relationships for the Fathead Minnow, 'Pimephales promelas': Narcotic Industrial Chemicals. |
| Author |
Veith, G. D. ;
Call, D. J. ;
Brooke, L. T. ;
|
| CORP Author |
Wisconsin Univ.-Superior. Center for Lake Superior Environmental Studies.;Environmental Research Lab.-Duluth, MN. |
| Year Published |
1983 |
| Report Number |
EPA-R-809234; EPA-600/J-83-070; |
| Stock Number |
PB84-110006 |
| Additional Subjects |
Toxicology ;
Fishes ;
Lethal dosage ;
Mammals ;
Reprints ;
Fathead minnows ;
Pimephales promelas ;
Toxic substances ;
Water pollution effects(Animals)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB84-110006 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
Narcosis is a reversible state of arrested activity of protoplasmic structures caused by a wide variety of organic chemicals. This nonspecific mode of toxic activity was found predominant in acute toxicity studies of industrial chemicals and fish. This paper presents 96-h LC50 values for 65 industrial chemicals including alcohols, ketones, ethers, alkyl halides, and substituted benzenes. The common mode of action permitted the development of a structure-toxicity relationship as follows: log LC50 = -0.94 log P + 0.94 log (0.000068P + 1) - 1.25 where P is the n-octanol/water partition coefficient. The data show that the toxicity of the chemicals to fish is directly comparable with the toxicity in mammals when expressed as chemical activity. |
