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Main Title Developmental toxicity of inhaled methanol in the CD-1 mouse, with quantitative dose--response modeling for estimation of benchmark doses
Author Rogers, John H. ; Rogers, J. M. ; Mole, M. L. ; Chernoff, N. ; Barbee, B. D. ; Turner., C. I.
Other Authors
Author Title of a Work
Mole, M. Leonard
Chernoff, Neil
Barbee, Brenda D.
Turner, Christine I.
Logsdon, Tina R.
Kavlock, Robert J.
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Developmental Toxicology Div. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC.
Publisher Environmental Protection Agency,
Year Published 1993
Report Number EPA/600/J-94/209
Stock Number PB94-163888
OCLC Number 47170737
Subjects Methanol as fuel--toxicity
Additional Subjects Teratogenic compounds ; Methanol ; Toxicity ; Dose-response relationships ; Congenital abnormalities ; Cleft palate ; Oral administration ; Blood ; Reprint ;
Library Call Number Additional Info Location Last
ELCD  EPA 600-J-94-209 NVFEL Library/Ann Arbor, MI 09/09/2011 STATUS
NTIS  PB94-163888 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation var. pagings 28 cm.
Pregnant CD-1 mice were exposed to 1,000, 2,000, 5,000, 7,500, 10,000, or 15,000 ppm on methanol for 7 hr/day on days 6-15 of gestation. On day 17 of gestation, remaining mice were weighed, killed and the gravid uterus was removed. Numbers of implantation sites, live and dead fetuses and resorptions were counted, and fetuses were examined externally and weighed as a litter. Significant increases in the incidence of exencephaly and cleft palate were observed at 5,000 ppm and above, increased postimplantation mortality at 7,500 ppm and above (including an increasing incidence of full-litter resorption), and reduced fetal weight at 10,000 ppm and above. A dose-related increase in cervical ribs or ossification sites lateral to the seventh cervical vertebra was significant at 2,000 ppm and above. Thus, the NOAEL for the developmental toxicity in this study is 1,000 ppm. The results of this study indicate that inhaled methanol is developmentally toxic in the mouse at exposure levels which were not maternally toxic. Litters of pregnant mice gavaged orally with 4 g methanol/kg displayed developmental toxic effects similar to those seen in the 10,000 ppm methanol exposure group. (Copyright (c) 1993 Wiley-Liss, Inc.)
"EPA/600/J-94/209." Includes bibliographic references. Caption title.