Record Display for the EPA National Library Catalog


Main Title Effect of Trichloroethylene on the Exploratory and Locomotor Activity of Rats Exposed during Development.
Author Taylor, D. H. ; Lagory, K. E. ; Zaccaro, D. J. ; Pfohl, R. J. ; Laurie, R. D. ;
CORP Author Miami Univ., Oxford, OH. Dept. of Zoology.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA-R-809618; EPA/600/D-85/191;
Stock Number PB85-245967
Additional Subjects Toxicology ; Rats ; Laboratory animals ; Exposure ; Behavior ; Ethylene/trichloro ; Locomotor activity ; Water pollution effects(Animals)
Library Call Number Additional Info Location Last
NTIS  PB85-245967 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
Trichloroethylene (TCE) is a common contaminant of underground water supplies. To examine the effect of TCE on the developing central nervous system, rats were exposed to TCE throughout gestation until 21 days postpartum via their dams' drinking water. TCE concentrations of 312 ppm, 625 ppm and 1250 ppm were tested. Exploratory behavior was higher in 60- and 90-day old male rats which were exposed to any level of TCE. The effect of TCE-exposure on locomotor activity (running wheel) was also examined in 60-day old males (625 and 1250 ppm exposure groups). Locomotor activity was significantly higher in rats exposed to 1250 ppm TCE. These data suggest that TCE has long-term effects on behavior.