The paper gives results of an investigation of the effect of catalytic incinerator design and operation on the destruction of specific volatile organic compounds (VOCs), both singly and in mixtures. A range of operating and design parameters were tested on a wide variety of compounds and compound mixtures. Conclusions of the study, presented here as applying only to the test catalyst and ranges of conditions tested, include: (1) VOC destruction efficiency increases with increasing temperature and concentration, and with decreasing space velocity; (2) the destructibility of VOCs varies according to compound class; (3) individual VOCs have different destruction efficiencies (at a given concentration, temperature, and space velocity); and (4) different destruction efficiencies may be obtained for a specific VOC incinerated in a mixture vs. burned alone.